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Lakshmanan, P

In contrast, during the withdrawal phase, GLP-1RAs appear to exert effects through broader circuits involving the lateral septum, hypothalamus, and brainstem nuclei, modulating stress responsivity, negative affect, and somatic symptoms, as evidenced in models of opioid and nicotine withdrawal

Tirzepatide, marketed as Zepbound for weight management, has shown higher average weight loss than semaglutide in many trial comparisons

More isn't always better

It is not FDA approved

However, certain patient populations require careful consideration and individualized risk-benefit assessment before initiating therapy