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Pehar M, ORiordan KJ, Burns-Cusato M, Andrzejewski ME, del Alcazar CG, Burger C, Scrable H, Puglielli L (2010) Altered longevity-assurance activity of p53:p44 in the mouse causes memory loss, neurodegeneration and premature death

Severe or persistent nausea and vomiting that prevents adequate food or fluid intake, as this may lead to dehydration and acute kidney injurycontact your GP urgently or call NHS 111 for advice Signs of hyperglycaemia including excessive thirst, frequent urination, blurred vision, or unexplained fatigueparticularly relevant as corticosteroids can precipitate or worsen diabetes Symptoms of hypoglycaemia (if also taking diabetes medications) such as trembling, sweating, confusion, or rapid heartbeat Visual changes or severe headaches seek prompt assessment, especially if you have diabetes or are at risk of glaucoma Mood changes or psychological symptoms , as corticosteroids can affect mental health Signs of infection , as corticosteroids suppress immune function Before starting Wegovy whilst on corticosteroid therapy, patients should inform their healthcare provider about: All current medications, including over-the-counter preparations and supplements Any history of pancreatitis, thyroid disease, or diabetic retinopathy Previous adverse reactions to GLP-1 receptor agonists Plans for surgery or medical procedures Regular follow-up appointments are essential for patients taking both medications to monitor treatment response, adjust doses as needed, and address any emerging concerns

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Similarly, in the SURMOUNT-1 trial, all participants received lifestyle intervention which included regular counseling with a dietitian or qualified health professional to achieve a 500 kcal/day energy deficit and 150 minutes of physical activity weekly