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Id also raise the question of whether the incretins and other GLP-1 agonists will ever be free of adverse GI symptoms, as it seems intrinsic to the drugs mechanism.
Unlike the well-known roles of GLP-1 and #PYY, the role of INSL5 is poorly understood, but this new research suggests it promotes colonic motility and in fact may be behind the cases of severe diarrhea (bile acid malabsorption in #IBS)
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The peripherally restricted CB1R inverse agonist JD-5037 arrested the initiation of insulitis in humans and mice
Research on the experimental drug petrelintide suggests it is much less likely to cause nausea and vomiting than GLP-1 drugs, but the pace of weight loss is more moderate.
