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Significant anti-inflammatory effects were shown by a high dose of semaglutide, which caused the microglia polarization shifting to M2 as shown by lessening the concentrations of TNF- and i-NOS to 38.29 and 43.48%, respectively, in contrast to elevating arginase-1 and IL-4 to 1.89- and 2.55- folds, respectively, in comparison with reserpine group (Fig

Key details: Covered medications : Wegovy (injection and tablet), Zepbound, and Foundayo

New England Journal of Medicine , 387 (3), 205216

As more trials emerge in the future showing the effect of discontinuation of OMMs on weight and obesity-related complications, the extent of weight regain and worsening of clinical outcomes will become clearer 60