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In addition, a large number of clinical studies have shown that GLP-/GIP dual agonists can reduce LFC, VAT, and body weight, and have an improvement effect on both NAFLD and NASH [131,132]

These searches have been reproduced with almost identical results (66), leading to the definition of acute pancreatitis as an adverse event of special interest in clinical trials of GLP-1RAs

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The mechanisms proposed for this protective effect include modulation of inflammatory pathways, reduction of oxidative stress, and improvement of metabolic parameters that contribute to liver carcinogenesis (Wang et al., 2024)

doi: 10.1097/SCS.0000000000010588 [DOI] [PubMed] [Google Scholar] 29

University Hospital and University of Basel