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How it feels: Because retatrutide is still experimental, most people havent experienced it yet outside of clinical trials

People who lose weight rapidly face substantially higher risk than those who lose gradually

While some studies found no difference between individuals with T2DM and matched non-diabetic controls (6769), others found plasma DPP-4 activity to be reduced in the patients, and suggested this might reflect a compensatory response to the reduced insulin sensitivity and hyperglycaemia, in an attempt to increase intact incretin hormone concentrations and improve insulin secretion (70, 71)

While early Phase 2 data show a promising efficacy profile, the full side effect picture is still emerging

43 Subsequent preclinical research utilising enzyme-resistant long-acting GIP peptides, as well as genetic manipulation of the GIPR, reinforced these early findings