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Early trials in people with diabetes showed fewer major cardiovascular events
This difference in receptor targeting may influence their efficacy and side effect profiles
CrossRef PPAR Alpha as a Metabolic Modulator of the Liver: Role in the Pathogenesis of Nonalcoholic Steatohepatitis (NASH) Simona Todisco, Anna Santarsiero, Paolo Convertini, Giulio De Stefano, Michele Gilio, Vito Iacobazzi, Vittoria Infantino Biology.2022
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It suggests the drug is working reliably through its intended mechanism rather than producing results via a confounding factor
