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However, in a recent abstract, the interim analysis of the REGENERATE trial showed lower patient-reported outcomes than the general population on a specific questionnaire (the chronic liver disease questionnaire-NASH), and the patient-reported outcomes improved with OCA treatment

Willemsen et al., 2011)

Ive lost 60 pounds

Kidney Failure: People who already have kidney problems have more risk, especially if they get dehydrated
A study in healthy volunteers explored the vasodilatory and headache-inducing properties of GLP-1, revealing no significant differences in post-infusion headache between GLP-1 and placebo [30]

No other approved or late-stage investigational compound does this
