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Key Takeaways Retatrutide is a triple hormone receptor agonist that targets both fat loss and muscle preservation, enabling weight management for obesity

Both the injections and pills have similar side effects, including nausea, constipation, vomiting, gallbladder disease, and other gastrointestinal issues

These symptoms typically occur during dose escalation and often diminish with continued use, but they may be more pronounced in patients with altered gastrointestinal anatomy following surgery

Do safety signals change over longer follow-up

In phase 2 clinical trials, this drug improved body weight, body fat, and glycated hemoglobin (HbA1c) levels in people with obesity, with or without T2D

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