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In a 68-week clinical trial, patients treated with GLP-1 experienced an average weight loss of 14.9% from their initial body Trusted Source Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial Rubino D, Abrahamsson N, Davies M, et al Go to Source weight

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Because cagrilintide works through amylin receptors rather than GLP-1 receptors , it produces appetite suppression through a mechanism that does not overlap with semaglutide or tirzepatide