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Across all studies, the safety profile was consistent with the broader GLP-1 class: nausea, diarrhea, and mild gastrointestinal symptoms were the most common side effects, typically occurring during the dose escalation phase

When GLP-1 agonists reduce the dopamine rush associated with cravings, they also dial down the brains broader reward tone

Daily formulations of GLP-1 RAs, including exenatide BID, liraglutide, and lixisenatide, require dose selection and attachment of a disposable needle each time the injection device is to be used

[DOI] [PubMed] [Google Scholar] 13.Nielsen J, Friedman S, Norgard BM, Knudsen T, Kjeldsen J, Wod M

SOPHIA has received funding from the Innovative Medicines Initiative (IMI) 2 Joint Undertaking under grant agreement no

7 , 9 , 10 The differences in the indications reflect differences in CV risk of the populations enrolled in the CV outcomes trials