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In one study, people without diabetes who took semaglutide (the active ingredient in Ozempic and Wegovy) were slightly more likely to be diagnosed with ED than those taking a placebo

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Oral Semaglutide: Absorption Challenges and Clinical Considerations Oral semaglutide tablets must navigate stomach acid and enzyme degradation before absorption in the small intestine, resulting in approximately 12% bioavailability compared to the injected form