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Patients with a history of retinopathy should undergo ophthalmologic evaluation before initiating therapy and be monitored closely during treatment, as determined by the prescribing clinician

Key drug interactions with methotrexate include: Non-steroidal anti-inflammatory drugs (NSAIDs) may increase methotrexate levels, though many can be used with caution at low-dose methotrexate with appropriate monitoring Trimethoprim and co-trimoxazole are contraindicated due to increased folate antagonism Proton pump inhibitors may affect methotrexate levels, particularly with high-dose methotrexate regimens Certain antibiotics, particularly penicillins, that can reduce renal clearance Patients taking methotrexate require regular blood monitoring, including full blood count, liver function, and renal function

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If deemed ineligible, you will receive a full refund within 24-48 hours

Your provider can switch medications based on your response without penalty or additional sign-up fees

It requires a prescription from a licensed healthcare provider and is available under brand names like Ozempic, Wegovy, or as compounded peptides