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Patients with pre-existing cardiovascular risk factors should be monitored appropriately when initiating tirzepatide therapy, particularly during dose escalation when gastrointestinal effects are most pronounced
While semaglutide has more established data, retatrutide may become a powerful option for those who havent responded to other medications

The VISTA and SOLSTICE phase 2b trials evaluated the use of the glucagon-like peptide-1 receptor agonist (GLP-1 RA) elecoglipron in adults

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