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doi: 10.1007/s11154-021-09699-1

Eligible participants were required to have no history with drug use, psychiatric or neurological illnesses, heart conditions, high blood pressure, pregnancy and glaucoma

The dosing schedule follows a careful titration pattern: 2.5mg for the first four weeks, then 5mg, then increases of 2.5mg every four weeks as tolerated up to a maximum of 15mg weekly