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KFF reports that policymakers and insurers are increasingly evaluating strategies to manage the financial impact of GLP-1 coverage, particularly within Medicare and Medicaid programs where long-term costs could become significant

American Diabetes Association: New GLP-1 Therapies Enhance Quality of Weight Loss by Improving Muscle Preservation

Indeed, the 5-HT3 receptor antagonist ondansetron (Zofran) and the NK1R antagonist aprepitant (Cinvanti) are both prescribed treatments for chemotherapy-induced nausea and vomiting

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With the popularity of GLP-1 agonists ever-increasing and over 150 GLP-1 drug candidates in development [3], the field is continually expanding, most recently into oncology and obesity-related cancers.[4] While most approved GLP-1RAs require subcutaneous injection, substantial work is being undertaken to move toward oral GLP-1 therapies [5], such as Rybelsus which was the first oral GLP-1RA approved by the FDA in 2019

They are made based on a personalized prescription that may not be commercially available elsewhere or when a drug appears on the FDAs shortage list