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While this risk has not been confirmed in humans, it remains a consideration in patient selection and monitoring

Avoid injecting into scarred, bruised, hard, or irritated skin

Semaglutide (a GLP-1R monoagonist) achieved mean weight reductions of approximately 1517% in the STEP clinical trial programme (STEP-1, NEJM 2021)

Skipping doses or not following the dosing schedule can diminish the medications effectiveness

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By reversing the order, you prioritize the most important macronutrient for body composition