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Genetics Current studies are evaluating if a genetic predisposition or cause for gastroparesis exists, and have found implicated genes and pathways related to immune and sensorymotor dysregulation, though further studies are needed to fully understand their significance or contribution [54]

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[23] [24] Prochlorperazine (Compazine) and promethazine (Phenergan) are alternative options but may cause significant sedation and anticholinergic effects

However, regulatory guidance states that when the ratio of the area under the concentration-time curve (AUC) of the victim drug with and without the perpetrator drug falls outside the range of 0.81.25, there is a potential risk of a clinically significant impact, necessitating further investigation.146 The rationale for selecting the victim drugs was based on their being commonly used or a narrow therapeutic index, with different Biopharmaceutics Classification System (BCS) classifications.124 The list of victim drugs that have been investigated to confirm the magnitude of DDIs caused by delayed gastric emptying is as follows: acetaminophen, metoprolol and oral contraceptives (BCS Class I)
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Furthermore, a 2026 review published in BMJ Medicine found that people taking GLP-1 medications regained weight significantly faster than those who had lost weight through diet and exercise alone
