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Activation of GLP-1 receptor and GIP receptor alters gastric emptying, intestinal motility, and gut secretions

In contrast to established GLP-1 receptor agonists such as Semaglutide (marketed as Wegovy and Ozempic) or dual-acting agents like Tirzepatide, Retatrutide is designed as a triple agonist that simultaneously activates GLP-1, GIP, and glucagon receptors

Increased energy, better blood sugar control, improved appetite regulation, and clothes fitting differently often appear before the scale shows dramatic changes

However, other experts, like researchers at the University of Southern California, think GLP-1s would have much greater cost savings, estimating theyd save up to $245 billion in the first 10 years if private insurers also covered the medications

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