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In a phase I clinical trial, patients who were overweight or obese were able to reduce their body weight by 4.8% (3 mg dosage), 6.4% (4.5 mg), and 6.0% (6 mg) after receiving a once-weekly dose of mazdutide [51]

These effects are processed by a specific sequence of neurotransmitters beginning within domains of the ARC that consist of orexigenic neurons expressing neuropeptide Y (NPY) and Agouti-related peptide (AgRP) as well as domains that consist of anorexigenic neurons expressing pro-opiomelanocortin, POMC (yielding the neurotransmitter -MSH) and cocaine and amphetamine-regulated transcript (CART)

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However, given the presence of GLP-1R in the ARC and the direct contact of the ARC with the circulation, it is plausible that GLP1-RAs could have a direct effect on the hypothalamus, on the proviso that GLP-1RA levels exceed physiological levels of GLP-1

These drugs do more than lower glucose