glp 1 if not obese Weight loss with GLP-1 medicines does result in a disproportionate loss of muscle mass or function in mice and humans: Cell Reports Medicine Considering GLP-1 drugs for weight
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The exact mechanism isn't fully understood, but it may relate to blood sugar fluctuations, reduced calorie intake when starting the medication, or dehydration, especially if nausea limits fluid consumption

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Semaglutide in Reducing Body Weight: A Systematic Review and Meta-Analysis. 2025
284: R1427R1435 [DOI] [PubMed] [Google Scholar] 156.Goke R, Larsen PJ, Mikkelsen JD, et al

Resistant maltodextrin promotes fasting glucagon-like peptide-1 secretion and production together with glucose tolerance in rats

22, 23 Energy balance was calculated as 24-h energy intake minus EE
