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Several pharmacological therapies used to treat nutritional obesity and metabolic dysfunction, or those that have targeted pathways disrupted due to pathogenic variants (eg, setmelanotide in POMC deficiency), have been trialed in patients with HO, with variable success limited to a small number of patients [54]
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doi: 10.2337/db16-1344

GLP-1 analogs exert several biological activities connected not only with an insulinotropic effect but also with immunoregulation and reduction of inflammation
