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Also, patients may also taper their medication if they are considering pregnancy, says Lofton, who notes that its generally recommended to discontinue a GLP-1 agonist two months prior to a planned pregnancy

In some patients, gastrointestinal side effects can be severe enough to lead to treatment discontinuation

Packaging: Peptides should be stored in airtight containers, ideally under vacuum or in an inert atmosphere (such as nitrogen), to prevent oxidative damage

While experts say the new dose could benefit patients who need additional weight loss, they caution that higher doses may increase side effects

Upon activation of adenosine monophosphate (AMP)-activated protein kinase (AMPK), berberine enhances insulin sensitivity, reduces hepatic glucose output, and has been shown in animal models to increase GLP-1 secretion, although this mechanism has not yet been confirmed in large human trials