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Notably, GLP-1R deletion in primary mouse astrocytes results in subtle mitochondrial dysfunction accompanied by a compensatory enhancement of glucose transporter-1-mediated aerobic glycolysis [22]

Additionally, social media influencers , wellness podcasts , and mainstream health magazines have flooded the market with content explaining how GLP-1s work and who theyre for

Annu Rev Physiol 76: 535-559, 2014

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Beyond glycemic control, activating GLP-1R exerts anti-inflammatory and antifibrotic effects on diverse fibrotic diseases, such as renal fibrosis, cardiac fibrosis, liver fibrosis and BLM-induced pulmonary fibrosis [25, 26]

Finally, its important to be aware that many patients have had very bad experiences previously with healthcare professionals and may be sensitized to any perceived judgement or stigma