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Reduced hepatic bilirubin clearance can be due to defective (i) unconjugated bilirubin uptake and intrahepatic storage, (ii) conjugation of glucuronic acid to bilirubin (e.g., Gilbert syndrome, CriglerNajjar syndrome, LuceyDriscoll syndrome, breast milk jaundice), (iii) bilirubin excretion into bile (DubinJohnson syndrome), or (iv) conjugated bilirubin re-uptake (Rotor syndrome)

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The Tale of Two Drugs: Amid the weight-loss drug frenzy, the India heads of Eli Lilly and Novo Nordisk makers of the worlds most coveted obesity drugs lay out their playbooks ahead of the March expiry of semaglutides patent

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Poddar S et al