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And here we see in IQVIAs two charts the declining share of traditional diabetes therapies with growing new prescriptions for GLP-1 agonists a 5% share in 2019 and a 16% share in 2023

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We employ variants of the peptides GLP-1 and exendin-4 to explore the interplay between helical propensity near the agonist N-terminus and the ability to bind to and activate the receptor