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For a while, one of the big worries in obesity pharmacotherapy has been pretty simple: when body weight drops fast, how much of that is fat, and how much is the tissue you really want to keep

Active-treatment exposure totaled 51,346 patient-years, including 47,749 patient-years for semaglutide and 3,598 patient-years for tirzepatide

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Heightened susceptibility of females to the aversive effects of GLP1R agonists could therefore involve increased activation of these brain circuits