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Participants who began at lower doses and increased incrementally reported better tolerability than those who escalated more rapidly

Kasagga A, Assefa A, Amin MN, et al

A study found that while some participants regained weight after stopping semaglutide, many retained a portion of their weight loss by continuing with lifestyle modifications

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The thigh also provides a large rotation area, which matters for weekly injections that need consistent site variation

Understanding the escalation schedule - and when the provider would recommend moving the dose up or down - helps you know what to expect and what to report