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and 3) Use of SA as the primary outcome, defined as pregnancy loss occurring before 20 weeks of gestation

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Hence, it's regularly used as a base in flavored tobacco products, suggesting why it's a staple in the tobacco industry

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Of the overall study participants, 24.0% of mothers and 12.4% of fathers had completed primary school, while 38.6% of mothers and 53.3% of fathers had a university-level education (Table 1)

S -nicotine extracted from tobacco was considered safer and more economical.9 Analyses by Reynolds in 1967 and Ligget and Myers in 1978 came to the same conclusion.10 11 Stereoselective synthetic pathways for S -nicotine were developed later.12 However, while the tobacco industry eagerly pursued the stereoselective synthesis of L-menthol, developed by Nobel Laureate Ryji Noyori at the flavour manufacturer Takasago (Tokyo, Japan),13 the Truth Documents library does not contain any more recent evidence considering the use of synthetic racemic or S -nicotine by the major tobacco companies