glp 1 google scholar Emerging Frontiers in GLP-1 Therapeutics: A Comprehensive Evidence Base (2025) Oral GLP-1-Based Therapeutics in the

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While the doublet arms (trevogrumab alone added to semaglutide) showed tolerability roughly comparable to semaglutide monotherapy, the triplet arm had significantly more problems: 7 A 28.3% discontinuation rate is a significant clinical hurdle

By offering a medication that passively reduces alcohol consumption, GLP-1RAs could intervene at earlier stages of problematic drinking, potentially preventing escalation to more severe AUD

However, it is contraindicated (should not be used) in individuals with a personal or family history of Medullary Thyroid Carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

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For one, rapid weight loss (whether from medication, diet, or other lifestyle habits) is known to temporarily disrupt hormonal levels