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This can help patients feel more confident about making lifestyle changes particularly dietary changes that play an important role in weight management. Monitoring and follow-up with a healthcare provider While on any of these drugs, you'll need regular monitoring from your provider

While many studies have shown that dual agonists (GLP-1R/GIPR agonists) and tri-agonists (GLP-1R/GIPR/GCGR agonists) improve glycemia and body weight in amounts unprecedented by the single agents (Nauck & D'Alessio 2022), only a few have investigated their role in cardiovascular outcomes

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[DOI] [PMC free article] [PubMed] [Google Scholar] 55.Abdullahi S., Olatunji G.A

Activation of GLP-1R by exendin-4 could promot the osteogenic differentiation and inhibite adipogenic differentiation through regulating PKA/-catenin signaling pathway (Meng et al., 2016)