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GLP-1 RAs may need to be combined with other agents targeting the clearance of A or -synuclein to achieve a more effective disease-modifying outcome

Administered as a subcutaneous weekly injection, it is a manifold single pharmacological agent that has the ability to significantly lower glucose levels, as well as improve insulin sensitivity, reduce weight and amend dyslipidemia favorably modifying the lipid profile

doi: 10.1001/jama.2022.0078 76 US National Institutes of Health

As evidence from ongoing clinical trials and real-world studies accumulates, future guidelines are expected to evolve toward more personalized and comprehensive strategies for DKD management

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After exploring a number of new molecules, Thornberry and her colleagues hit upon sitagliptin