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The field is currently moving toward unimolecular polypharmacology (Jimenez-Solem et al., 2010)

The area under the curve (AUC) was calculated using the trapezoidal rule in Prism

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doi: 10.1016/j.drudis.2016.01.016 66 GimenoD.KivimakiM.BrunnerE

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