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Impaired incretin-induced amplification of insulin secretion after glucose homeostatic dysregulation in healthy subjects

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Major cardiovascular outcome trials, including LEADER, SUSTAIN-6, and REWIND, followed patients for several years

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The exact mechanisms underlying tirzepatide-induced weight loss remain to be clarified

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Current obesity reports , 10 , 14-30

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Moreover, premenopausal women have a markedly greater GLP-1 response to intraduodenal glucose than men, with the 60-minute area under the curve 2.5-fold higher in women (77)

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When these cells detect the presence of nutrients from the food weve eaten, they release GLP-1

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