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(Frontiers) Antisense oligonucleotide targeting NNMT in metabolic tissues: effects on methylation and metabolic syndrome

View Protocol Complete dosage protocol and reconstitution guide for TB-500 (10 mg Vial)

Clinical studies revealed dysregulations of HSL expression and activity in disorders, such as lipodystrophy, obesity, type 2 diabetes and cancer-associated cachexia

In 3-AR knockout mice, however, no effect was observed with AOD9604 confirming the dependency of its chronic lipolytic action on 3-AR expression, while also suggesting an additional acute mechanism that may operate through a separate pathway

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