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The how long reconstituted peptides last article explains why 28 days is the safety boundary

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Fralick, M., Chen, S

doi: 10.1007/s12031-007-9002-1 132 ViolletBGuigasBGarciaNSLeclercJForetzMAndreelliF

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Meta-analysis of 34 trials showed that among GLP-1 receptor agonists, once-daily exenatide has the lowest risk of vomiting, while albiglutide had the highest risk for diarrhea
