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During the semaglutide shortage, the FDA allowed compounding pharmacies to produce essentially a copy of Novo Nordisks Wegovy and Mounjaro

A 48-week protocol at 12mg maintenance requires approximately 432mg total

It also reduced pain by up to an average of 4.5 points (or 75.8 percent)

While the drug is largely eliminated within 5 weeks of the last dose, the pharmacodynamic effectsthe actual clinical impact on blood glucose and appetitemay begin to wane earlier as concentrations fall below therapeutic thresholds

Effect of Berberine on Cardiovascular Disease Risk Factors: A Mechanistic Randomized Controlled Trial

Pair it with Bifidobacterium longum at 5 billion CFU for its motility-enhancing effects
