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The advantages of using GLP-1RAs go beyond their anti-obesity and glucose-lowering effects, encompassing a reduced risk of major adverse cardio-nephro-vascular and hepatic outcomes by lowering arterial hypertension and overall improving metabolic function [49, 50]

Proc Natl Acad Sci USA 105, 50345039 (2008)

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The four conditions were (1) no treatment (blue line), (2) microneedle application only (red line), (3) saline delivery with the microneedle device (green line), and (4) insulin delivery with the microneedle device (purple line) (each from three rats)

This investigation is crucial, as IBS remains a condition for which finding effective treatment can be challenging, given its multifactorial nature and the variability in symptoms and triggers among patients

However, this may be difficult to determine as the degree of -cell destruction prior to surgery may be more critical in determining whether those -cells can recover sufficiently to resolve T2DM (6)