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Description
High-quality randomised controlled trials have shown that semaglutide can reduce belly fat levels by 16% after 26 weeks of treatment
When mitochondrial function is impaired, it can lead to reduced energy availability, oxidative stress, and contributes to a range of metabolic disorders, including insulin resistance and obesity
Activation of central GLP-1R influences satiety, nausea, and memory formation, as GLP-1 also acts as a brain stem neurotransmitter [16, 17]
Hence, we can only speculate that differences in initial BMI and change in BMI following pharmacotherapy would have driven greater weight loss in those patients with SG
Your appetite drops, you eat less, and if that means less protein and fewer calories than your body needs for basic function, fatigue follows
Diabetes Obes Metab 2023;25:101123.PubMed 112
