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If you are curious about what those first weeks feel like, the initial experience on semaglutide varies considerably from person to person, though most people notice appetite suppression within the first one to two weeks

doi: 10.2337/db19-0324 35 CatalanoKJMadduxBASzaryJYoungrenJFGoldfineIDSchaufeleF

In a phase 2 trial published in The New England Journal of Medicine , retatrutide produced substantial weight loss in adults with obesity or overweight over 48 weeks, with the highest-dose groups achieving reductions that reached up to 24.2%

We understand the importance of maintaining muscle mass and function as part of a sustainable weight loss regimen, alongside the many other challenges you may be facing

And if you ever decide to switch medications, the guide on switching from tirzepatide to semaglutide or exploring alternatives to tirzepatide covers the transition process

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