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The approval, for patients with MASH with moderate to advanced liver scarring, was based on results of the Phase III MAESTRO-NASH trial, where the MASH resolved in 25.9% of patients who received an 80-mg dose of Rezdiffra and 29.9% of those taking 100 mg, with no worsening of fibrosis

Figure 4 shows that the blue points, which are the estimates of the leave-one-out pooled log RR, all three of them were in close proximity to the overall effect estimate (red marker)

Individual metabolic characteristics, including baseline insulin sensitivity, body mass index, and the presence of prediabetes or type 2 diabetes, appear to influence incretin hormone secretion patterns

Body mass index alone does not predict eating disorder risk and using it as the primary metric for GLP-1 candidacy misses a significant proportion of people who need a more careful evaluation

Understanding both conditions is essential before considering combined treatment approaches

GLP-1 receptor agonists in alcohol use disorder and alcohol-associated liver disease