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Other GLP-1 Agonists Based on published clinical trial data, here's how retatrutide's side effect profile compares: Key observations: Retatrutide shows similar or lower GI side effect rates compared to maximum doses of competing peptides The glucagon receptor component doesn't appear to significantly increase side effect burden Discontinuation rates are comparable across all three agents Heart rate effects may be slightly lower with retatrutide The takeaway: retatrutide's trial-reported safety profile is at or below semaglutide and high-dose tirzepatide on the metrics that matter nausea, diarrhea, vomiting, discontinuation