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--- Pharmacokinetics Absorption: ~50% orally Onset of action: 1 hour Half-life: 69 hours (longer in renal impairment) Excretion: Mainly via kidneys (unchanged drug) --- Adverse Effects Common: Fatigue, dizziness, bradycardia, cold extremities, sleep disturbances

Marvel and colleagues have developed a 6-step process for innovators to consider in taking a concept to product

But stopping cold turkey typically produces appetite rebounds that are far harder to manage

Drowsiness increases when combined with diphenhydramine

Appetite and Digestion Changes Wegovy works by mimicking the GLP-1 hormone involved in hunger and fullness signals, helping many patients reduce calorie intake over time

When travelling, use an insulated medication bag with a cool pack (ensuring the pen does not come into direct contact with ice or frozen gel packs, which could cause freezing)