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In patients, low doses of aspirin (75 mg-2 gm/day) cause retention of uric acid by inhibiting uric acid secretion

Affordable Care Act Marketplace plans often cover GLP-1 drugs, such as Ozempic, that have been approved for treatment of type 2 diabetes, but seldom cover those approved for obesity, like Wegovy and Zepbound

Risk Factors: Rapid weight loss Older age Low protein diet Lack of resistance training Pre-existing low muscle mass Classification Mild: Minor flattening, mostly cosmetic

Newer incretin-based therapies and considerations for pregnancy Emerging therapies that target multiple incretin pathways such as Retatrutide (a triple agonist targeting GLP-1, GIP and glucagon receptors) and Cagrisema (a dual agonist mimicking GLP-1 and amylin) will require thorough investigation for their safety and efficacy in pregnancy

Pancreatic islets and cells also express GLP-1R, therefore GLP1 binding can also inhibits glucagon and stimulates somatostatin release (de Heer, Rasmussen, Coy & Holst, 2008