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Each week, about half of the medication is cleared, and by week five, only a tiny amount remains

Matching was separately performed for the GLP-1 RA, DM control, and non-DM control groups, targeting individuals from the GLP-1 RA group included in both matches

Combination with SGLT2 inhibitors to augment the benefits of this drug class in HFrEF with, for example, the weight-lowering effects of GLP-1 RA could offer a clinically valuable and feasible option addressing the spectrum of abnormalities associated with this HF phenotype

The article does not mention any specific side effects of increasing GLP-1 levels
Abutair AS, Naser IA, Hamed AT

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