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For most patients with good skin tone, the skin tightens naturally, minimizing the chance of lax or loose skin

For individuals seeking a controlled, science-backed method for managing weight, GLP-1 therapy offers a promising path forward

Excellent article Adam Johnson

The majority of the reported events occurred in patients who experienced gastrointestinal reactions leading to dehydration such as nausea, vomiting, or diarrhea

This is significant because it is the natural site of action of the GLP1-RAs and most relevant to their uses in diabetes and appetite control

Historically, this increased insulin response mediated by GLP-1 and GIP had been attributed to factors termed incretins (derived from incretion, a term used at that time to refer to a secretion that remains inside the body), hence the name incretin effect is still used today to describe the rise in insulin mediated by the action of these hormones