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The SURPASS-2 trial (PubMed ID 34170647) reported greater HbA1c reductions with tirzepatide versus semaglutide 1 mg in type 2 diabetes cohorts, while SURMOUNT-1 (PubMed ID 35658024) documented substantial body-weight reductions versus placebo in obesity cohorts

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Species differences Of note, GIPR agonists and GIP-1R agonists alone failed to increase the beating rate in RA or FOC in LA (Neumann et al

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Patients who took Ozempic in a 2021 clinical trial lost nearly 15% of their body weight