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Lillys research pipeline thus goes beyond tirzepatide

In patients with T2DM and hepatic steatosis, Cuthbertson et al

The CRF neurons of the hypothalamus express GLP1 receptors, and GLP1 receptor stimulation has been shown to enhance CRF signalling (Kinzig et al., 2003

Considering the large variety of therapies available, each with different attributes and mechanisms of action, along with the heterogenous nature of T2DM, the treatment landscape is understandably complicated

The combination is most commonly considered when a patient is in the early titration phase of tirzepatide and wants appetite suppression while the GLP-1/GIP effects are still building

And of course, these are preliminary Phase 2 topline results