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Tirzepatide demonstrated significant and superior weight loss compared to placebo in two pivotal studies

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2025 Case report describes female sexual dysfunction temporally associated with GLP-1 agonists including semaglutide (hypothesis-generating mechanism)

Ribeiro-Silva JC, Tavares CAM, Girardi ACC

The degree to which the patient adheres strictly to the other rules of the medical weight reduction program also has a significant impact on the weight loss outcome timeline

The most frequently reported adverse effects of tirzepatide in pivotal clinical trials were predominantly gastrointestinal in nature, consistent with the drug class mechanism of delayed gastric emptying