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This is usually reserved for patients who meet very specific criteria and are monitored closely

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For the treatment of obesity, GLP-1RAs and GIP/ GLP-1RAs are indicated in patients with a body mass index (BMI) 30 kg m 2 , or 27 kg m 2 in the presence of at least one weight-related comorbidity, to support weight reduction [23]

They guide patients through initial periods of dose adjustment and help interpret changes in body response

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For reference, the rate of discontinuation in the semaglutide study referenced above was 4.5% around half the rate of orforglipron with a longer trial period
